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Prognostic Indicators

A prognosis is a doctor's best estimate of how a disease will affect an individual and how it is likely to respond to treatment.

There are a number of factors that affect the prognosis of a person with multiple myeloma. Some of the most commonly recognized factors are summarized in the chart below. 

Routine laboratory tests Indicators of more active disease 
Beta 2 microblobulin (ß2M) Higher levels
Serum albumin Lower levels
Serum creatinine Higher than normal
Lactate dehydrogenase (LD or LHD) Higher than normal
C-reactive proytein (CRP) Higher than normal
Hemoglobin (red blood cells) Lower than normal
Platelet count Lower than normal
Special tests Indicators of more active disease
Plasma cell labeling index (PCLI) High percentage of plasma cells 
Plasma cell morphology

Presence of immature plasma cells (plasmatic morphology)

Chromosome analysis or FISH (cytogenetic testing)

Absence of chromosome 13 and other cytogenetic abnormalities

Bone marrow microvessel density (MVD) Growth of new blood vessels in the bone marrow

For more information, download the Multiple Myeloma Patient Handbook
Designed to provide educational support to patients, caregivers, families, and friends, this handbook gives accurate, reliable, and clear information on myeloma. Topics cover its causes and effects, how it is diagnosed, and the treatment options available in Canada.
Download it now.